All of the appetite suppressants work by causing the release of two chemicals, named nor-epinephrine and epinephrine. The release of these chemicals causes the feeling of less hunger or not hungry at all. Obviously, if you are not fighting hunger, it is easier to eat less in any program for weight loss.
The consumer version of the PDR (Physicians’ Desk Reference) says that people should take appetite suppressants only for a short period of time, and under the supervision of doctors. When you build up tolerance for these appetite suppressants, you should stop using them.
The most common side effect of the appetite suppressants is jitters, which people sometimes feel weird and have a sense that their heart is beating faster.
The main appetite suppressants on the market include phentermine, phendimetrazine, diethylpropion, benzphetamine and sibutramine (meridia). Among the appetite suppressants, only sibutramine or meridia is approved for long term use in the obesity treatment in program for weight loss. Another type of weight loss pill that has been approved for long term use is xenical, the category of digestive inhibitors.
In fact, all appetite suppressants have a potential for abuse. That is why it only can be use for a short period of time. And, all of these appetite suppressants except phentermine are somewhat old-fashioned and are rarely used nowadays.
Sibutramine | Meridia
Being one of the diet pills that approved by FDA for long term use, sibutramine is originally studied as an antidepressant but it does not perform well. During the studies on depression, it is found to cause weight loss effect, that subsequently be used as an appetite suppressants.
Sibutramine works directly on the centers in the brain that tell you that you are full or satisfied. In addition, these appetite suppressants can raise metabolism as it can stimulate brown fat metabolism. Brown fat is a particular kind of fat that causes the body to burn calories.
Although studies with rodents show that there is a 30% increase in metabolism with these appetite suppressants, however it has a different result when studies are carried in humans. In fact, studies in human body reveal that these appetite suppressants may stimulate brown fat metabolism, but only by approximately 2% to 4% and for less than 24 hours.
Other studies reveal some weight loss results after using these appetite suppressants. However, evidence accumulated in the clinical trials suggests that the effectiveness of these appetite suppressants is less than impressive. Total annual weight reduction tends to be in the range of 8-20 pounds. In addition, the highest weight loss tends to be achieved by patients who participate in supervised trials involving a combination of appetite suppressants and diet, exercise as well as counseling. This makes it difficult to ascertain the precise effect of the appetite depressants on itself.
Apart from that, study published at Canadian Medical Association Journal in May 2002 reveals that FDA in the United States received reports of 397 adverse events related t to these appetite depressants, including 143 cardiac arrhythmias. In the United Kingdom, there were 215 reports of 411 adverse reactions, including 95 serious ones. Besides, these appetite depressants were taken off the market in Italy after 50 adverse reactions and 2 deaths from cardiovascular causes reported in this country.
Even though you are allowed to take appetite suppressants pills under the supervision of the doctors, they normally include these weight loss pills as part of an overall program for weight loss. A good doctor will always advise their patients to review and make change of lifestyle and diet habit.
In a healthy program for weight loss, it is always recommended to understand the correct weight loss concept first. Apart from that, perform regular exercise as well as eat a well balanced diet are important to get a healthy body weight range.